Lipoproteins were separated from blood plasma utilizing the preparative ultracentrifuge. These electron microscopic photomicrographs were prepared by Robert Hamilton, Ph.D. of the Cardiovascular Research Institute, University of California, San Francisco. Magnification for the chylomicrons, (left panel) is 60,000. Magnification for the very low density lipoproteins (VLDL), low density lipoproteins (LDL), and high density lipoproteins (HDL) was 180,000. Pictures were taken after negative staining, and lipoproteins are visualized on a dark background.
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